Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 30
Filter
1.
Korean Journal of Pancreas and Biliary Tract ; : 172-176, 2018.
Article in English | WPRIM | ID: wpr-717612

ABSTRACT

Pancreas metastasis of primary lung cancer is known to be very rare and if it occurs, most cases are disseminated malignant status and do not affect therapeutic plan. We experienced a case of lung cancer recurrence with solitary pancreas metastasis and mimicks primary pancreatic cancer. A 54-year old man was admitted to the hospital for further evaluation of pancreatic solitary mass. He underwent left pneumonectomy and adjuvant chemotherapy for treatment of lung adenocarcinoma 3 years ago. After surgical treatment, the lesion was confirmed metastatic adenocarcinoma of lung cancer origin. He was discharged and followed up for 24 months without recurrence.


Subject(s)
Adenocarcinoma , Chemotherapy, Adjuvant , Lung Neoplasms , Lung , Neoplasm Metastasis , Pancreas , Pancreatic Neoplasms , Pneumonectomy , Recurrence
2.
Journal of Preventive Medicine and Public Health ; : 141-157, 2017.
Article in English | WPRIM | ID: wpr-123894

ABSTRACT

Social medicine is recognized as one of medical specialties in many countries. However, social medicine has never been formally introduced to Korea, presumably because the term and its principles were not accepted for some years in the past in American medicine, which has strongly influenced Korean medicine. This paper describes the origins and evolution of social medicine and briefly discusses contemporary social medicine in Korea. Social medicine was initiated in France and Germany in 1848. Since then, it has expanded globally and developed in diverse ways. Included in core principles of social medicine is that social and economic conditions have important effects on health and disease, and that these relationships must be subjected to scientific investigation. The term ‘social medicine’ is rarely used in Korea, but many of its subject matters are incorporated into preventive medicine which, besides prevention, deals with population health that is inescapably social. However, the Korean preventive medicine directs little attention to the basic concepts and principles of social medicine, upon which systematic development of social medicine can be based. Thus, it is necessary to supplement the social medicine contents of preventive medicine through formalizing the linkages between the two fields. One way of doing so would be to change the title of ‘preventive medicine’ course in medical colleges to ‘preventive and social medicine,’ as in many other countries, and to adjust the course contents accordingly.


Subject(s)
France , Germany , Korea , Preventive Medicine , Republic of Korea , Social Medicine
3.
Health Policy and Management ; : 246-255, 2016.
Article in Korean | WPRIM | ID: wpr-212449

ABSTRACT

The study of public health systems is an important, but very difficult task. The concept and functions of public health systems are influenced by the views, interests, and influence of the various stakeholders belonging to public health systems and broader social, economic, political, and environmental sectors. To define public health system with conceptual clarification, we must take into account the dynamic and complex aspect of the public health system. This paper reviews health systems and public health systems literature to suggest the concept, goals, and functions of public health systems. In addition, this paper recognizes some challenges, such as leadership and management, resource development, economic support, and service delivery to strengthen public health systems for improving health and well-being of population.


Subject(s)
Economic Development , Leadership , Public Health , Staff Development
4.
Journal of Preventive Medicine and Public Health ; : 236-243, 2014.
Article in English | WPRIM | ID: wpr-101973

ABSTRACT

OBJECTIVES: Despite the recent emphasis on a patient-centered chronic care model, few studies have investigated its use in older adults in South Korea. We explored how older Korean adults perceive and cope with their chronic illness. METHODS: We conducted focus group interviews in Seoul, Korea in January 2010. Focus groups were formed by disease type (hypertension and type 2 diabetes) and gender using purposive sampling. Inclusion criteria were patients aged 60 and over who had been diagnosed with diabetes or hypertension and received care at a community health center for at least six months prior to participation. Interview data were analyzed through descriptive content analysis. RESULTS: Among personal factors, most participants felt overwhelmed when they received their diagnosis. However, with time and control of their acute symptoms using medication, their worry diminished and participants tended to denying being identified as a patient or sick person. Among socio-familial factors, participants reported experiencing stigma with their chronic illness and feeling it was a symbol of weakness. Instead of modifying their lifestyles, which might interfere with their social relationships, they resorted to only following their medicine regime prescribed by their doctor. Participants also reported feeling that their doctor only prescribed medications and acted in an authoritative and threatening manner to induce and reinforce participants\' compliance with treatment. CONCLUSIONS: For successful patient-centered management of chronic illnesses, supportive environments that include family, friends, and healthcare providers should be established.


Subject(s)
Aged , Female , Humans , Male , Middle Aged , Chronic Disease , Community Health Centers , Diabetes Mellitus, Type 2/diagnosis , Disease Management , Focus Groups , Hypertension/diagnosis , Interviews as Topic , Life Style , Perception , Republic of Korea , Social Support
5.
The Korean Journal of Gastroenterology ; : 290-293, 2013.
Article in Korean | WPRIM | ID: wpr-45035

ABSTRACT

Biliary enteric fistula is an abnormal pathway often caused by biliary disease. It is difficult to diagnose the disease because patients have nonspecific symptoms. A 67-year-old woman presented with hematemesis and melena. She was diagnosed with Dieulafoy lesion on the gastric antrum and underwent endoscopic hemostasis using hemoclips. Follow-up upper gastrointestinal endoscopy revealed an abnormal opening on a previous treated site that was suggestive of biliary enteric fistula. Abdomen simple X-ray and abdominal dynamic CT scan showed pneumobilia and cholecysto-gastric fistula. The patient had cholecystectomy and wedge resection of the gastric antrum, followed by right extended hemicolectomy because of severe adhesive lesion between the gallbladder and colon. She was diagnosed with cholecysto-gastro-colic fistula postoperatively. We report on this case and give a brief review of the literatures.


Subject(s)
Aged , Female , Humans , Biliary Fistula/complications , Cholecystectomy , Endoscopy, Gastrointestinal , Gastric Fistula/complications , Gastrointestinal Hemorrhage/complications , Intestinal Fistula/complications , Tomography, X-Ray Computed
6.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 50-54, 2013.
Article in Korean | WPRIM | ID: wpr-143749

ABSTRACT

Emphysematous gastritis is a subtype of phlegmonous gastritis characterized by emphysematous change of the gastric wall. It is associated with infection of gas forming organism and is often fatal because of suppurative bacterial infection. Streptococci is the most commonly involved microorganism of emphysematous gastritis. Aspergillus is a very rare pathogen of this disease, because invasive aspergillosis often presents as pulmonary infections and rarely involves the gastro-intestinal tract. Treatment should be aimed to cover various organism using broad spectrum antibiotics, and sometimes aggressive surgical management may be needed to enhance survival. We report a case of severe emphysematous gastritis caused by invasive aspergillosis with a review of the literature.


Subject(s)
Anti-Bacterial Agents , Aspergillosis , Aspergillus , Bacterial Infections , Cellulitis , Gastritis
7.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 50-54, 2013.
Article in Korean | WPRIM | ID: wpr-143740

ABSTRACT

Emphysematous gastritis is a subtype of phlegmonous gastritis characterized by emphysematous change of the gastric wall. It is associated with infection of gas forming organism and is often fatal because of suppurative bacterial infection. Streptococci is the most commonly involved microorganism of emphysematous gastritis. Aspergillus is a very rare pathogen of this disease, because invasive aspergillosis often presents as pulmonary infections and rarely involves the gastro-intestinal tract. Treatment should be aimed to cover various organism using broad spectrum antibiotics, and sometimes aggressive surgical management may be needed to enhance survival. We report a case of severe emphysematous gastritis caused by invasive aspergillosis with a review of the literature.


Subject(s)
Anti-Bacterial Agents , Aspergillosis , Aspergillus , Bacterial Infections , Cellulitis , Gastritis
8.
Journal of Agricultural Medicine & Community Health ; : 111-130, 2012.
Article in Korean | WPRIM | ID: wpr-719839

ABSTRACT

OBJECTIVE: The purpose of this study was to identify and compare social capital measurement tools for the convenient use in public health studies. METHOD AND RESULT: This study examined and compared social capital tools developed individually by the World Bank, the OECD, the United States, United Kingdom, Canada, Australia, Ireland, and Korea. A comprehensive framework was constructed with six conceptual dimensions and sixteen indices. The six dimensions included Membership, Network, Trust, Information and communication, Social and civic participation, and Social cohesion and exclusion, which connoted the structural, cognitive, bonding, bridging, operative, and output elements. The indices of each tool were respectively matched to the indices of the comprehensive framework. The comprehensive tools were Integrated Questionnaire for the Measurement of Social Capital (SC-IQ) of the World Bank with 27 questions and the European Social Survey (ESS) of the OECD with 80 questions. CONCLUSION: The SC-IQ should be utilized in public health studies due to its simplicity yet comprehensiveness as a social capital tool. The ESS should also be considered as a comprehensive tool.


Subject(s)
Academies and Institutes , Australia , Canada , United Kingdom , Ireland , Korea , Public Health , United Nations , United States , Surveys and Questionnaires
9.
Journal of Agricultural Medicine & Community Health ; : 195-214, 2012.
Article in Korean | WPRIM | ID: wpr-719834

ABSTRACT

The New Public Health(NPH) is a comprehensive approach to protecting and promoting the health status of each individual member and society as a whole. NHP is not so much a philosophy to broaden the understanding of public health as it is an action plan to address current public health system. This paper's objectives include increasing public and professional awareness of the significant changes in the national public health systems of developed countries and contributing to more effective delivery of public health services in Korea. This paper reviews articles and documents concerning NPH and the public health system, and outlines of the achievements in developed countries since NPH movement began. These include the change in the definition and function of public health, expansion of public health networks, strengthening of public health policy, reorientation of public health delivery systems, promotion of workforce capacity, and the implementation of evidence-based management. To overcome the challenges facing the public health system of Korea, we must prioritize the value of population-based approach, expand the notion of a public health system to encompass all sectors that can influence health, promote a "Health in All Policies" approach, focus on an evidence-based health policy and program, develop core competencies for public health workers, and establish performance standards for public health organizations based on the core functions of public health.


Subject(s)
Achievement , Developed Countries , Health Policy , Korea , Philosophy , Public Health
10.
Yeungnam University Journal of Medicine ; : 133-144, 2011.
Article in Korean | WPRIM | ID: wpr-29013

ABSTRACT

BACKGROUND: Tigecycline (TIG), a new broad-spectrum glycylcycline with anti-multidrug-resistant-(MDR)-pathogen activity, was launched in March 2009 in South Korea, but there are insufficient clinical studies on its use in the country. As such, this study was performed to analyze cases of severe MDR-pathogen-caused infections treated with TIG. METHODS: Patients treated with TIG within the period from May 2009 to June 2010 were enrolled in this study. Their clinical and microbiologic data were reviewed retrospectively. RESULTS: Twenty-one patients were treated with TIG for complicated skin and soft-tissue infections (cSSTIs) (42.9%), complicated intra-abdominal infections (cIAIs) (38.1%), or pneumonia (19.1%) caused by MDR pathogens like carbapenem-resistant Acinetobacter baumannii (76.2%), methicillin-resistant Staphylococcus aureus (61.9%), extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae (38.1%), and penicillin-resistant Enterococcus species (33.3%). Thirteen patients (61.9%) had successful clinical outcomes while five (23.8%) died within 30 days. The rate of clinical success was highest in cSSTI (77.8%), followed by cIAI (50%) and pneumonia (50%), and the mortality rate was highest in pneumonia (50%), followed by cIAI (25%) and cSSTI (11.1%). CONCLUSION: Tigecycline therapy can be an option for the treatment of severe MDR-pathogen-caused infections in South Korea. Due to its high risk of failure and mortality, however, prudence is required in its clinical use for the treatment of severe infections like nosocomial pneumonia.


Subject(s)
Humans , Acinetobacter baumannii , Drug Resistance , Enterococcus , Escherichia coli , Intraabdominal Infections , Klebsiella pneumoniae , Methicillin-Resistant Staphylococcus aureus , Minocycline , Pneumonia , Republic of Korea , Skin , Tetracyclines
11.
Journal of Agricultural Medicine & Community Health ; : 87-100, 2011.
Article in Korean | WPRIM | ID: wpr-719998

ABSTRACT

OBJECTIVES: This study aimed to identify factors associated with smoking relapse. METHODS: The study sample was recruited among subjects who were enrolled in the smoking cessation clinic of a public health center and had succeeded in quitting smoking for at least six months. A total of 159 male subjects were followed via mail survey one year later. The independent variables in the analyses were socio-demographic characteristics, smoking history and behavior, receipt of smoking cessation aids, health behaviors and components of the health belief model (HBM). The dependent variable was smoking relapse assessed one year after quitting. Ordered logit regressions were used to identify factors associated with smoking relapse. RESULTS: The relapse rate of the ex-smokers in our sample was 25.8%, and the occasional smoking rate was 17.0%. Univariate analyses revealed that only factors related to the HBM, such as perceived susceptibility to diseases (p<0.01), perceived severity of diseases (p<0.01), perceived health benefits of not smoking (p<0.01), perceived barriers to quitting smoking due to increasing stress and difficulty in social life (p<0.01), and self-efficacy (p<0.01) were associated with the likelihood of relapse for ex-smokers. Ordered logit analyses yielded two significant factors affecting the likelihood of relapse, the perceived barriers to quitting smoking and self-efficacy. CONCLUSIONS: Our results indicate that higher levels of barriers to quitting smoking and lower levels of self-efficacy were significantly related to risk of smoking relapse. These findings may be useful for identifying those at highest risk for relapse and choosing the optimal strategies for prevention of relapse for ex-smokers.


Subject(s)
Humans , Male , Health Behavior , Insurance Benefits , Postal Service , Public Health , Recurrence , Smoke , Smoking , Smoking Cessation
12.
Journal of Agricultural Medicine & Community Health ; : 264-279, 2011.
Article in Korean | WPRIM | ID: wpr-719847

ABSTRACT

OBJECTIVES: The aims of this study were to evaluate the effect of a metabolic syndrome management program on participants enrolled in a public health center program in, Seoul, Korea for 6 months and to analyze the changes in their life habits and risk factors for treating their metabolic syndrome. METHODS: Participants enrolled in a metabolic syndrome program at a public health center and answered questionnaires. Their waist circumference and, blood pressure were measured and their blood was tested. Based on the results, the participants were classified into 3 groups. Then, the center provided a metabolic syndrome management intervention program for the individual groups and analyzed the changes in participants' life habits and risk factors after 6 months. RESULTS: After the intervention, the active group, showed improved physical activity, increased eating habits by 0.7 points, and decreased drinking and smoking; however, these results were not statistically significant. As for the Participants' overall health status, all groups positively changed a statistically significant result. In regard to the change in risk factors for metabolic syndrome in the active group, systolic and diastolic blood pressure and triglyceride levels were, statistically significantly decreased, meanwhile, an increase was found in HDL cholesterol level, waist measurement, and anteprandial glucose level; but the result were not statistically significant. Their review rate was 19.0%; 29.4% in the active group, 19.0% in motivating group A, and 14.5% in motivating group B. CONCLUSIONS: Participants showed changes in some life habits and risk factors, a result still far from the program's goal to improve residents' health status (improved living habits and variations in risk factors); thus, it is necessary to supplement this program for better performance.


Subject(s)
Blood Pressure , Cholesterol, HDL , Drinking , Eating , Glucose , Korea , Motor Activity , Public Health , Risk Factors , Waist Circumference , Surveys and Questionnaires
13.
Journal of Preventive Medicine and Public Health ; : 100-106, 2008.
Article in Korean | WPRIM | ID: wpr-15549

ABSTRACT

OBJECTIVES: We measured behavioral factors associated with Koreans receiving gastric cancer screening based on a socio-ecological model, in part to develop strategies to improve cancer screening rates. METHODS: A telephone survey was conducted with 2,576 people chosen through stratified random sampling from April 1- May 31, 2004. Collected information included gastric cancer screening, socio-demographic factors, and socio-ecological factors at intrapersonal, interpersonal, community, and public policy levels. RESULTS: Among 985 survey respondents (380 men and 605 women), 402 had received gastric cancer screening. Logistic analysis was performed to compare those screened and unscreened. 'Age' was the only demographic factor that showed a statistically significant association with getting screening. People in their fifties (OR=1.731, 95% CI=1.190-2.520) and sixties (OR=2.098, 95% CI=1.301-3.385) showed a higher likelihood of getting screened, compared to those in the forties. 'Accessibility to a medical institution' was a significant factor related to having gastric cancer screening at the intrapersonal level. At the interpersonal level, recommendations by family members to be screened and a family practice of routine cancer screening were significantly related. People with frequent education about cancer screening or with stronger social feelings that cancer screening is necessary also demonstrated significantly higher tendencies to be screened. CONCLUSIONS: In conclusion, a socio-ecological model seems appropriate for explaining gastric cancer screening behavior and associated factors. Health planners should develop integrated strategies to improve cancer screening rates based on socio-ecological factors, especially at the interpersonal and community levels.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Age Factors , Health Behavior , Health Knowledge, Attitudes, Practice , Health Services Accessibility , Korea/epidemiology , Social Support , Socioeconomic Factors , Stomach Neoplasms/diagnosis
14.
Korean Journal of Preventive Medicine ; : 80-87, 2004.
Article in Korean | WPRIM | ID: wpr-30681

ABSTRACT

OBJECTIVE: To evaluate the learning achievement and satisfaction levels for the Field Epidemiology Specialist Training Program (FESTP), on infectious disease control between March 19 and October 31, 2002. METHODS: The FESTP was designed as a set of 84 hours curricula including lectures, discussions, self-studies, and field practicals, and organized both centrally and locally by the Division of Communicable Disease Control of the National Institute of Health and 11 universities. Before and after the program, a questionnaire survey on the educational need (49 items) and satisfaction (15 items) was conducted on 484 trainees, who were responsible for communicable disease control and immunization at 242 regional health centers. The data were analyzed with paired t-tests for comparison of the educational needs between the pre and post scores. RESULTS: The average score for satisfaction was 3.06 out of 5.0; with relatively higher scores for sincerity (4.10) and professionalism (4.01) of the tutors, adequacy (3.54) and clearness (3.51) of the evaluation criteria, usefulness (3.54) and fitness (3.52) of the contents, but with relatively lower satisfaction for schedule (2.96) and self-studies (2.91). The average for requirement for education improved, as shown by the decrease from 2.72 to 2.22 (p< .0001) with the biggest decrease in the outbreak investigation from 2.60 to 2.08. CONCLUSION: The FESTP was evaluated as being effective, the trainees showed moderate satisfaction and decrease educational needs. However, the actual schedules and self-studies should be rearranged to improve the satisfaction level.


Subject(s)
Appointments and Schedules , Communicable Disease Control , Communicable Diseases , Curriculum , Education , Epidemiology , Immunization , Learning , Lecture , Professionalism , Specialization
15.
Korean Journal of Gastrointestinal Endoscopy ; : 199-204, 2003.
Article in Korean | WPRIM | ID: wpr-32423

ABSTRACT

BACKGROUND/AIMS: While colonoscopy is the gold standard diagnostic test for the detection of colorectal polyps (especially adenomas), it is also an imperfect method. We prospectively estimated the colonoscopic miss-rate of colorectal polyp and adenoma. METHODS: We performed polypectomies in 603 out of 2,006 patients over age of 40 who underwent their first time colonoscopy between September 1999 and June 2001. A follow-up colonoscopy was performed within 60 days in 235 (53.4%) among 440 enrolled patients. RESULTS: Seventy-three (31.0%) of 235 patients with polyps on initial colonoscopy were missed polyps and 37 (23.2%) of 159 patients with adenomas on initial colonoscopy were missed adenomas. As the number of polyps on the initial examination increased, the miss-rate increased significantly (p=0.01). The most frequent size of missed polyp was 3~4 mm (55.5%, p=0.00) and the most frequent location was sigmoid colon (27.3%, p=0.00). CONCLUSION: It may be a fallacy to declare that all colorectal polyps are removed just after one session of colonoscopy. Examiners should make every effort to reduce the miss-rate of colorectal polyps during colonoscopy.


Subject(s)
Humans , Adenoma , Colon, Sigmoid , Colonoscopy , Diagnostic Tests, Routine , Follow-Up Studies , Polyps , Prospective Studies
16.
Korean Journal of Preventive Medicine ; : 417-426, 2001.
Article in Korean | WPRIM | ID: wpr-196583

ABSTRACT

OBJECTIVES: To analyse the psychosocial factors associated with hypertension management(drug treatment and life style modification) of newly detected cases and to understand and assess their behavioral intention or behaviors. METHODS: The survey area was a combined urban and rural area in Chungnam province, Korea, and the sampling method was cluster sampling. Study subjects included 541 newly detected cases of hypertension rated above stage 2 by JNC-VI from a community survey. The first survey was applied to 383 of these patients in order to discern their psychosocial characteristics. A follow-up survey was given to 345 persons with an 11-month interval following monthly telephone counseling concerning medication and life style modification by trained nurses. The final study subjects for analysis comprised 271 persons after excluding cases of incomplete data and change of address. RESULTS: Among the 85(33.2%) new patients who had intended to undergo drug treatment, 30(35.3%) persons were treated with antihypertensive agent after 11- month interval, while among the patients with no intention to receive treatment, only 36(21.1%) persons were treated. Hypertensive patients with a high intention score revealed a high score in life style modification compliance as well. Seventy three percent of the variance of behavioral intention to undergo hypertension management was explained by the patients attitude toward performing the behavior and subjective norm associated with behaviors related to the theory of reasoned action in structural modeling. Actual behaviors related positively with behavioral intention. The coefficient of determination was 0.255. CONCLUSION: Improving the compliance level of hypertensive patients in respect to drug treatment or life style modification requires a build up of positive behavioral intention, and caregivers must pay more attention to eventually converting behavioral intention to actual behaviors.


Subject(s)
Humans , Caregivers , Compliance , Counseling , Data Collection , Follow-Up Studies , Hypertension , Intention , Korea , Life Style , Models, Structural , Psychology , Telephone
17.
Journal of the Korean Geriatrics Society ; : 68-75, 2000.
Article in Korean | WPRIM | ID: wpr-226614

ABSTRACT

Background : Health service needs for the elderly is rapidly increasing in Korea. Comprehensive functional status assessment is essential for effective and rational allocation of health service resources for the elderly. We assessed the validity of Korean version of Resident Assessment Instrument-Minimum Data Set Home Care Version(MDS-HC), which is comprehensive, client centered, and enabling the prediction of resources utilization.


Subject(s)
Aged , Humans , Dataset , Health Services , Home Care Services , Korea
18.
Journal of the Korean Medical Association ; : 733-738, 2000.
Article in Korean | WPRIM | ID: wpr-210717

ABSTRACT

No abstract available.


Subject(s)
Delivery of Health Care , Health Care Reform , Korea
19.
Korean Journal of Medicine ; : 477-482, 2000.
Article in Korean | WPRIM | ID: wpr-119522

ABSTRACT

Barium carbonate is commonly used rodenticidally and industrially, but intoxication has been uncommonly reported. Muscle weakness and hypokalemia are the characteristic features of barium carbonate intoxication. Barium-induced hypokalemia is due to a rapid and large transfer of potassium from the extracellular space into the intracellular space resulting from blocking potassium channels by barium ions. We report 35 cases of barium carbonate intoxication which developed after accidental ingestion of barium poisoned noodle. All patients developed severe hypokalemic paralysis and some degree of vomiting and diarrhea. We managed these patients with aggressive potassium supplementation and all patients were discharged without any sequelae.


Subject(s)
Humans , Barium , Carbon , Diarrhea , Eating , Extracellular Space , Hypokalemia , Intracellular Space , Ions , Muscle Weakness , Paralysis , Potassium , Potassium Channels , Vomiting
20.
Korean Journal of Infectious Diseases ; : 217-224, 1999.
Article in Korean | WPRIM | ID: wpr-176083

ABSTRACT

PURPOSE: Despite the advancement in chemotherapy and supportive care, a persisting problem in patients with leukemia is infectious complications, which are the leading cause of death. We evaluated infectious complications in acute leukemic patients to understand the current features and also evaluated risk factors for death in acute leukemia. METHODS: The medical records of 186 cases of acute leukemia who underwent chemotherapy in St. Mary's Hospital between January 1995 and December 1997 were reviewed. And we compared these data to our previous data published in 1994. RESULTS: One hundred (95%) cases among 126 leu- kemic patients who received induction chemotherapy and 42 (70%) of 60 cases who received consolidation chemotherapy experienced at least one febrile episodes during treatment. Microbiologically defined infection (MDI), clinically defined infection (CDI), and unexplained fever (UF) were evenly distributed. In MDI, the isolation rate of gram positive organism was markedly increased but that of fungus was decreased. The common clinical manifestations were bacteremia, pneumonia, neutropenic enterocolitis, and catheter infection, in the order of decreasing frequency. The overall mortality rates reduced from 50% (early of the 1980s) to 12.9%, but the infection-related mortality increased up to 80% in spite of improvement in supportive care, antimicrobials and administration of hematopoietic growth factors. Refractory or relapsed acute myelogenous leukemia (AML) had 5 times higher risk of death than primarily diagnosed AML and MDI had 10.9 times higher risk of death than UF. And one more febrile day increased the risk of death by 1.4 times. CONCLUSION: Infection is still the most important cause of morbidity and mortality in acute leukemia patients. Dominant infecting organisms are changing from gram-negative bacilli to gram-positive cocci. New preventive, diagnostic, and treatment strategies should be developed and prophylactic use of antimicrobials should be restricted as much as possible to prevent emergence of resistant microorganisms.


Subject(s)
Humans , Bacteremia , Catheters , Cause of Death , Consolidation Chemotherapy , Drug Therapy , Enterocolitis, Neutropenic , Fever , Fungi , Gram-Positive Cocci , Induction Chemotherapy , Intercellular Signaling Peptides and Proteins , Leukemia , Leukemia, Myeloid, Acute , Medical Records , Mortality , Neutropenia , Pneumonia , Risk Factors
SELECTION OF CITATIONS
SEARCH DETAIL